Press Release: Novartis data at EULAR 2026 demonstrates momentum for broad immunology portfolio for complex, high unmet need diseases

-- New Cosentyx(R) (secukinumab) data from REPLENISH, largest ever global

Phase III trial in polymyalgia rheumatica, to be highlighted in oral

session

-- New ianalumab interim results from Sjögren's Phase III extension

study up to week 108 and Phase II data in systemic lupus erythematosus

will be presented

Basel, June 1, 2026 -- Novartis will present new data from 31 abstracts across its industry-leading immunology portfolio at the European Alliance of Associations for Rheumatology (EULAR) Congress on June 3-6 in London, advancing scientific insight into high-burden autoimmune diseases.

"Novartis is committed to shaping the future of immunology. From small molecules to biologics and CAR-T cell therapy, our pioneering science is focused on where we can have the greatest impact on patient outcomes," said Angelika Jahreis, Global Head, Immunology Development, Novartis. "At EULAR, we will share compelling new data for Cosentyx, ianalumab and our CAR-T therapy rap-cel across diseases where there is high unmet need. These data demonstrate how Novartis innovation can have meaningful impact for people living with autoimmune diseases like polymyalgia rheumatica, Sjogren's disease, systemic lupus erythematosus and systemic sclerosis."

Key abstracts accepted by EULAR include:

Molecule/Disease Abstract Title Number/Presentation Details

Cosentyx(R) (secukinumab)

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Polymyalgia Rheumatica Secukinumab in polymyalgia rheumatica: Results of OP0116

the phase 3 REPLENISH trial Oral Presentation

June 3, 4:30pm-4:40pm BST

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Secukinumab in patients with polymyalgia rheumatica: POS0019

Subgroup analyses of Week 52 results of a Phase 3, Poster Tour Presentation

multicentre, randomised, double-blind, placebo-controlled June 3, 3:30pm-4:30pm BST

trial (REPLENISH)

--------------------------------------------------- ------------------------------------------------------------- ---------------------------

Psoriatic Arthritis Impact of Early Biologic Use With Secukinumab on Radiographic POS0474

Progression in Psoriatic Arthritis: A Pooled Analysis Poster Tour Presentation

of the FUTURE 1 and FUTURE 5 Trials June 3, 3:30pm-4:50pm BST

--------------------------------------------------- ------------------------------------------------------------- ---------------------------

Rap-cel (rapcabtagene autoleucel, YTB323)

-----------------------------------------------------------------------------------------------------------------------------------------------

Systemic Sclerosis and Severe Refractory Idiopathic Safety and Early Efficacy of Rapcabtagene Autoleucel, OP077

Inflammatory Myopathies an Autologous CD19 Directed Chimeric Antigen Receptor Oral Abstract Presentation

T-Cell Therapy, in Severe Refractory Idiopathic Inflammatory June 3, 4:40pm-4:50pm BST

Myopathies and Diffuse Cutaneous Systemic Sclerosis:

Preliminary Analysis of the Open-Label AUTOGRAPH-IIM

and --SSC studies

--------------------------------------------------- ------------------------------------------------------------- ---------------------------

Systemic Lupus Erythematosus Clinical, Cellular Kinetics, Pharmacodynamics and POS0303

Biomarker Data Up to 24 Months After Rapcabtagene Poster Tour Presentation

Autoleucel (YTB323), a Rapidly Manufactured CD19 CAR-T June 5, 4:00pm-5:00pm BST

Therapy, From an Open-Label, Phase 1/2 Study in Severe

Refractory SLE

--------------------------------------------------- ------------------------------------------------------------- ---------------------------

Ianalumab

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Sjögren's Disease Efficacy and Safety of the Ianalumab Global Phase OP0126

3 Studies (NEPTUNUS-1 and NEPTUNUS-2) and Their Extension Oral Presentation

Study in Patients With Sjögren's Disease June 3, 4:50pm-5:00pm BST

--------------------------------------------------- ------------------------------------------------------------- ---------------------------

Systemic Lupus Erythematosus Safety and Efficacy of Subcutaneous Ianalumab (VAY736) OP0335

Post-B Cell Recovery in Patients with Systemic Lupus Oral Presentation

Erythematosus: End of Study Results from a Phase 2 June 5, 8:15am-8:25am BST

Study

--------------------------------------------------- ------------------------------------------------------------- ---------------------------

About Novartis Immunology

At Novartis, we're advancing bold science with the goal of bringing relief and a renewed sense of hope to people living with autoimmune diseases. Building on our legacy of first-in-class innovation across rheumatology, dermatology and allergy, and a diverse industry-leading pipeline, we're committed to shaping what's next in Immunology.

Product Information

For full prescribing information, including approved indications and important safety information about marketed products, please visit https://www.novartis.com/about/products.

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About Novartis

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